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. 2008 Sep 11;3(9):e3189. doi: 10.1371/journal.pone.0003189

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Hatada et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Several astrocyte-specific genes are already demethylated in E14.5 NPCs; however, they are induced after diffentiation to astrocytes. This could be explained by astrocyte-specific transcription factors.