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. 2008 Sep 12;4(9):e1000190. doi: 10.1371/journal.pgen.1000190

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Jones et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A representative X-gal stained 7.5-dpc Dot1L^3lox/+ embryo demonstrating ubiquitous Dot1L transcription throughout the embryo. (B) A representative X-gal stained 9.5-dpc Dot1L^3lox/+ embryo demonstrating ubiquitous Dot1L transcription throughout the embryo with elevated Dot1L expression in the indicated regions. (C) A representative X-gal stained 9.5-dpc Dot1L^3lox/+ yolk sac demonstrating Dot1L transcription in visceral endoderm, visceral mesoderm, and primitive erythrocytes. (D) Representative pictures of 9.5-dpc Dot1L^1lox/+ and Dot1L^1lox/1lox embryos. Dot1L^1lox/+ embryos (left) were indistinguishable from wild-type embryos. Most Dot1L^1lox/1lox embryos were undersized, had an enlarged heart (cardiac dilation) and stunted tail (center), while approximately 15% exhibited developmental arrest at E8.5 (right). (E) Representative pictures of a 10.5-dpc Dot1L^1lox/1lox embryo (right) and a heterozygous littermate (left). (F) Representative pictures showing the yolk sac vasculature of 9.5-dpc Dot1L^1lox/+ (left) and Dot1L^1lox/1lox (right) embryos. The vasculature of the Dot1L^1lox/1lox yolk sac is thinner and less organized than that of the heterozygous littermate.