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. 2008 Sep 12;4(9):e1000190. doi: 10.1371/journal.pgen.1000190

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Jones et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Confocal microscopy images showing either TRF1 (telomere marker, green), PML (marker for PML bodies, red), or combined fluorescence (yellow if colocalize, indicated by arrows) in wild-type (+/+) and Dot1L-deficient (1lox/1lox) ES cells. Late-passage (p120) Dnmt3a/3b-deficient (3a−/−3b−/−) ES cells were used as a positive control. Circled are nuclei of cells. (B) Quantification of percentage of cells showing colocalization of telomeres with PML bodies. A cell was considered positive when it showed 2 or more colocalization events. An increased frequency of cells showing APBs was observed in Dot1^1lox/1lox cultures compared to wild-type controls (χ² test, P<0.001). (C) Quantification of the number of APBs per cell. Dot1^1lox/1lox cells showed a significant increase in the number of APBs compared to wild-type cells (χ² test, P<0.001).