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. 2008 Aug 29;337:a1331. doi: 10.1136/bmj.a1331

Table 3.

 Stent thromboses in trials with dual antiplatelet therapy of six months or more

Variable Events Relative risks (95% credibility interval)
BMS PES SES Total SES v BMS PES v BMS SES v PES
ARC definite stent thrombosis*
Patients with diabetes:
 No of patients at risk 557 874 753 2184
 0 days to 4 years 13 17 9 39 0.33 (0.09 to 1.09) 0.82 (0.23 to 3.09) 0.40 (0.13 to 1.08)
 0-30 days 11 9 6 26 0.25 (0.04 to 1.11) 0.39 (0.05 to 2.36) 0.60 (0.12 to 3.36)
 >30 days to 4 years 2 8 3 13 0.72 (0.04 to 10.8) 3.54 (0.23 to 78.6) 0.20 (0.02 to 1.04)
Patients without diabetes:
 No of patients at risk 2439 3130 2647 8216
 0 days to 4 years 34 56 46 136 1.24 (0.58 to 3.08) 1.48 (0.69 to 3.40) 0.84 (0.41 to 1.88)
 0-30 days 19 22 28 69 1.19 (0.43 to 3.09) 1.11 (0.38 to 2.97) 1.06 (0.41 to 2.90)
 >30 days to 4 years 15 34 18 67 1.19 (0.43 to 4.13) 1.83 (0.67 to 5.85) 0.65 (0.26 to 1.70)
Per protocol definition of stent thrombosis†
Patients with diabetes:
 No of patients at risk 723 912 870 2505
 0 days to 4 years 16 18 7 41 0.20 (0.05 to 0.68) 0.73 (0.19 to 2.80) 0.27 (0.07 to 0.80)
 0-30 days 11 10 5 26 0.23 (0.03 to 1.08) 0.55 (0.09 to 3.05) 0.42 (0.07 to 1.89)
 >30 days to 4 years 5 8 2 15 0.10 (0.01 to 0.93) 0.87 (0.06 to 10.3) 0.11 (0.01 to 0.75)
Patients without diabetes:
 No of patients at risk 2577 3382 2625 8584
 0 days to 4 years 29 58 46 133 1.48 (0.74 to 3.41) 1.80 (0.89 to 3.67) 0.82 (0.44 to 1.73)
 0-30 days 22 24 28 74 1.11 (0.47 to 2.81) 0.99 (0.44 to 2.33) 1.15 (0.48 to 2.72)
 >30 days to 4 years 7 34 18 59 2.29 (0.83 to 7.77) 4.12 (1.55 to 13.1) 0.55 (0.25 to 1.27)

BMS=bare metal stent; PES=paclitaxel eluting stent; SES=sirolimus eluting stent.

*According to Academic Research Consortium criteria.

†According to protocol definitions used in individual trials.