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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Eur Neuropsychopharmacol. 2008 Mar 4;18(8):551–556. doi: 10.1016/j.euroneuro.2008.01.002

Figure 3.

Figure 3

Total dopamine D2 and D2High receptors in the dorsal striatum of no-drug control animals and animals given limited or extended access to self-administered cocaine, either 3 or 30 days after the last self-administration session. Panel a shows the total number of D2 receptors ([3H]domperidone binding) in the cocaine-treated groups expressed as a percent of the control group. There were no group differences in the total number of D2 receptors (Overall ANOVA, group, F(2,40)=.03, p=.97). Panel b shows the proportion of D2High receptors, again with the cocaine-treated groups expressed as a percent of the control group. In control animals the proportion of D2 high affinity receptors was 18±1.4%. Cocaine self-administration experience greatly increased the proportion of D2High receptors at both 3 and 30 days of withdrawal [main effect of group, F(2,42)=68.89, p<.0001, main effect of withdrawal time, F(1,42)=.65, p=.43, group by time interaction, F(2,32)=2.8, p=.07, *, differs from the no drug group as determined by Bonferroni’s corrected t-tests].