TABLE 1.
Parameter values for the SMC model
| Parameter | Description | Value |
|---|---|---|
| F | Maximal rate of activation dependent calcium influx. | 0.23 μM/s |
| Kr | Half saturation constant for agonist-dependent calcium entry. | 1 μM |
| GCa | Whole cell conductance for VOCCs. | 0.00129 μM mV−1 s−1 |
| vCa1 | Reversal potential for VOCCs. | 100.0 mV |
| vCa2 | Half-point of the VOCC activation sigmoidal. | −24.0 mV |
| RCa | Maximum slope of the VOCC activation sigmoidal. | 8.5 mV |
| GNa/Ca | Whole cell conductance for Na+/Ca2+ exchange. | 0.007 μM mV−1 s−1 |
| cNa/Ca | Half-point for activation of Na+/Ca2+ exchange by Ca2+. | 0.5 μM |
| vNa/Ca | Reversal potential for the Na+/Ca2+ exchanger. | −30.0 mV |
| B | SR uptake rate constant. | 2.025 μM/s |
| cb | Half-point of the SR ATPase activation sigmoidal. | 1.0 μM |
| C | CICR rate constant. | 55 μM/s |
| sc | Half-point of the CICR Ca2+ efflux sigmoidal. | 2.0 μM |
| cc | Half-point of the CICR activation sigmoidal. | 0.9 μM |
| D | Rate constant for Ca2+ extrusion by the ATPase pump. | 0.08 s−1 |
| vd | Intercept of voltage dependence of extrusion ATPase. | −100.0 mV |
| Rd | Slope of voltage dependence of extrusion ATPase. | 250.0 mV |
| L | Leak from SR rate constant. | 0.025 s−1 |
| Gstretch | Whole cell conductance for SACs. | 0.0061 μM mV−1 s−1 |
| ESAC | Reversal potential for SACs. | −18 mV |
| α | Slope of stress dependence of the SAC activation sigmoidal. | 0.0074 mmHg−1 |
| σ0 | Half-point of the SAC activation sigmoidal. | 500 mmHg |
| γ | Scaling factor relating net movement of ion fluxes to the membrane potential (inversely related to cell capacitance). | 1970 mV/μM |
| FNa/K | Net whole cell flux via the Na+-K+-ATPase. | 0.2 μM/s |
| GCl | Whole cell conductance for Cl− current. | 0.00134 μM mV−1 s−1 |
| vCl | Reversal potential for Cl− channels. | −25.0 mV |
| GK | Whole cell conductance for K+ efflux. | 0.002 μM mV−1 s−1 |
| vK | Reversal potential for K+. | −94.0 mV |
| λ | Rate constant for net KCa channel opening. | 45.0 |
| cw | Translation factor for Ca2+ dependence of KCa channel activation sigmoidal. | 0 μM |
| β | Translation factor for membrane potential dependence of KCa channel activation sigmoidal. | 0.13 μM2 |
 |
Half-point for the KCa channel activation sigmoidal. | −27.0 mV |
| RK | Maximum slope of the KCa activation sigmoidal. | 12.0 mV |
| k | Rate constant of IP3 degradation. | 0.1 s−1 |