Table 1.

Medical subject heading (MeSH) thesaurus keywords used for online literature searches in PubMed and Cochrane databases. The last online search was performed on 07/01/2008

Compound	MeSH-Terms
Cannabinoids	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Endocannabinoids” OR “Dexabinol” OR “Cannabinoids” OR “Anandamide”
Glutamate (NMDA) Receptor Antagonists	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “EAA” OR “Excitatory Amino Acid” OR “Neuroprotective Agent” OR “NMDA” OR “N-Methyl-D-Aspartate”
Magnesium sulfate (MgSO4)	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Magnesium-Chloride” OR “Magnesium Compounds” OR “ Magnesium” OR “Magnesiumsulfate”
Corticosteroids	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Steroids” OR “Glucocorticoids” OR “Corticosteroids” OR “Cortisone” OR “Prednisolone” OR “Dexamethasone” OR “Methylprednisolone”
Aminosteroids	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Aminosteroids” OR “Tirilazad” OR “Lazaroid”
Progesterone	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Progesterone” OR “Sexual Hormones”
Monoaminergic substances	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Amphetamine” OR “Dopamine” OR “Methylphenidate” OR “Dextroamphetamine”
Cyclosporine	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Cyclosporine” OR “Immunosuppressant” OR “Cyclosporine A” OR “ CsA”
Ca-Channel Blockers	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Calcium Channel Blocker” OR “Calcium Antagonist” OR “Nifedipine” OR“Verapamil” OR “Nicardipine” OR “Nimodipine” OR “Amlodipine” OR “Felodipine” OR “Diltiazem”
Inflammatory Modulators	“Traumatic Brain Injury” OR “Closed Head Injury” OR “Brain Injury” OR “TBI” OR “Brain Damage” AND “Kallikrein-Kinin” OR “Bradykinine Receptor Antagonists” OR “Kinins” OR “Bradycor” OR “Anatibant”