Fig. 3.
Neutrophil depletion eliminates the protective effects of increased epithelial cell nuclear factor kappa-B activation in Pseudomonas aeruginosa pneumonia. (a) Lung lavage neutrophil and macrophage counts from four groups of neutrophil depleted mice: wild-type (WT), WT + doxycycline (Dox), cIKK2 TransActivated (IKTA) and IKTA + Dox. Dox was added to drinking water 2 days prior to infection and mice were harvested at 24 h after after intratracheal injection of PA103 [1 × 105 colony-forming units (cfu)]. (b) P. aeruginosa colony counts per right middle lobe (RML) from mice harvested 24 h after i.t. injection of 1 × 105 cfu of PA103 (n = 5 per group).