Table 1.
Mediator concentration in bronchoalveolar lavage (BAL) (pg/ml).
| WT + Dox | IKTA + Dox | WT + Dox + PA | IKTA + Dox + PA | |
|---|---|---|---|---|
| IL-1α | 0 | 0 | 33 (14) | 96 (5)* |
| IL-1β | 0 | 56 (6) | 100 (15) | 141 (16) |
| IL-6 | 0 | 342 (165) | 254 (111) | 1818 (341)* |
| IL-12 (p40) | 32 (4) | 37 (13) | 69 (2·3) | 128 (30) |
| G-CSF | 0 | 236 (81) | 713 (167) | 2961 (652)* |
| GM-CSF | 0 | 12 (10) | 30 (18) | 224 (34)* |
| MIP-1α | 0 | 0 | 286 (138) | 1143 (191)* |
| MIP-2 | 0 | 48 (15) | 26 (6) | 381 (90)* |
| KC | 12 (2) | 65 (11) | 196 (75) | 985 (117)* |
| RANTES | 0 | 356 (40) | 708 (231) | 4604 (2039)* |
| TNF-α | 0 | 35 (12) | 164 (53) | 510 (130)* |
| IFN-γ | 0 | 0 | 0 | 27 (17)* |
Values measured by luminex or enzyme-linked immunosorbent assay are presented as mean (± standard error of the mean); n = 3–6 per group.
*
P < 0·05 compared with all other groups by analysis of variance. Dox, doxycycline; G-CSG, granulocyte colony-stimulating factor; GM-CSF, granulocyte–macrophage colony-stimulating factor; IKTA, cIKK2 TransActivated; IL, interleukin; IFN, interferon; KC, keratinocyte chemoattractant; KC, keratinocyte chemoattractant; MIP, macrophage inflammatory protein; RANTES, regulated upon activation normal T cell expressed and secreted; TNF, tumour necrosis factor; WT, wild-type.