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. Author manuscript; available in PMC: 2008 Aug 31.
Published in final edited form as: Biochemistry. 2006 Nov 30;45(51):15216–15223. doi: 10.1021/bi0619021

Figure 5.

Figure 5

Model of the LpxC-substrate complex based on the X-ray crystal structures of the TU-514 complex (22) and the UDP complex (Figure 3). Atoms are color coded as follows: C= light cyan O = red, N = blue, P = orange; the substrate carbon atoms appear in black; zinc ions appears as grey spheres; solvent molecules appear as red spheres. Intermolecular interactions observed in the two complexes separately can be achieved by an intact molecule of the substrate, UDP –{3-O-[(R)-3-hydroxymyristoyl]}-N-acetylglucosamine (Figure 2A), bound in the active site.