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. Author manuscript; available in PMC: 2008 Aug 31.
Published in final edited form as: J Med Chem. 2005 Dec 29;48(26):8261–8269. doi: 10.1021/jm050765n

Scheme 1.

Scheme 1

Reagents: Reagents: a) K2CO3, DMSO, 90 °C, 8 h for 6 and 24 h for 7; b1) H2, pd/c, EtOAc-MeOH, room temp., 8 h; b2) For 12c and 12h; SnCl2.2H2O, EtOAc, refluxm 2 h.; c) 11, CH2Cl2, Et3N, room temp.