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. 1999 May;10(5):1337–1351. doi: 10.1091/mbc.10.5.1337

Figure 1.

Figure 1

Steps in API import via the Cvt and autophagy pathways. Details are discussed in INTRODUCTION. Step 1: prAPI dodecamerization; step 2: Cvt complex formation; step 3: recognition and membrane sequestration; step 4: membrane expansion and vesicle completion; step 5: targeting, docking, and fusion of the Cvt vesicle or autophagosome with the vacuole; step 6: release of the Cvt body or autophagic body into the vacuole lumen; step 7: breakdown of the Cvt body or autophagic body and maturation of API.