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. 2008 Sep 11;3(9):e3180. doi: 10.1371/journal.pone.0003180

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Richards et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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B6 mice were injected with PBS or EL4 and sacrificed after 21 days. A. FACs profile of early hematopoiesis. HSCs are characterized as Lin⁻CD127⁻Sca1⁺cKit⁺ while the CLP is characterized as Lin-CD127⁺Sca1⁺cKit⁺. B. Characterization of NKPs as CD3⁻CD122⁺NK1.1⁻DX5⁻. C. Characterization of B cells by B220. D. Absolute numbers of HSCs, CLPs, NKPs, and B cells. Each line and symbol represents the mean of separate experiments involving 5 mice per group. A paired T test (one-tail) was used to determine whether tumor growth reduced the number of HSC, CLP, NKP and B cells. FACS data shown in A–C are representative of those obtained from 5 independent experiments, involving a total of 5 mice per group.