Pharmacological inhibition of PARP (for 2 months) does not affect the cardiac remodeling and lung edema associated with advanced aging. Left ventricular (LVW), right ventricular (RVW), atrial (AW) and lung (LungW) weights in young adult (Y), young adult treated with INO-1001 (Y+INO), aging (A), and aging treated with INO-1001 (A+INO) male Fischer rats were normalized to body weight (BW). Values are mean ± S.E.M. of 6 to 10 experiments in each group. *, P < 0.05 versus young adult controls.