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Pharmacological inhibition of PARP (for 2 months) improves ESPVR (Emax), PRSW, +dP/dt-EDV, EDPVR, and efficiency in advanced aging-associated heart failure. Overall values of Emax, PRSW, dP/dt-EDV, EDPV relationships, and efficiency. Values as mean ± S.E.M. of 6 to 10 experiments in each group. *, P < 0.05 versus young adult; #, P < 0.05 versus aging.
