Table 3.
SNP name |
Location | Gene (Allele) | NIMH | German | Combined | |||||
---|---|---|---|---|---|---|---|---|---|---|
Case freq |
Control freq |
p-value | Case freq |
Control freq |
p-value | p-value | OR (CI) | |||
rs12410676a | 1p13.3 | VAV3 (G) | 0.895 | 0.867 | 0.061 | 0.884 | 0.857 | 0.024 | 0.004 | 1.28 (1.09-1.51) |
rs13414801 | 2p23.2 | BRE (C) | 0.696 | 0.628 | 0.001 | 0.658 | 0.660 | 0.913 | 0.056 | ns |
rs4148776a | 2q31.3 | ABCB11 (T) | 0.062 | 0.042 | 0.049 | 0.055 | 0.048 | 0.418 | 0.062 | ns |
rs1131171 | 2q37.1 | NCL (G) | 0.842 | 0.809 | 0.048 | 0.828 | 0.805 | 0.104 | 0.013 | 1.20 (1.04-1.38) |
rs7610043 | 3p24.1 | RBMS3 (G) | 0.567 | 0.492 | 0.0008 | 0.523 | 0.499 | 0.124 | 0.001 | 1.21 (1.08-1.35) |
rs9863764a | 3p26.1 | GRM7 (G) | 0.131 | 0.109 | 0.137 | not genotyped | ||||
rs3762685a | 3q24 | PLSCR4 (C) | 0.391 | 0.307 | 7.5×10−5 | 0.373 | 0.354 | 0.293 | 0.0009 | 1.22 (1.08-1.36) |
rs4411993 | 4p16.1 | SORCS2 (C) | 0.907 | 0.864 | 0.003 | 0.888 | 0.862 | 0.030 | 0.0005 | 1.35 (1.14-1.61) |
rs7683874b | 4p16.1 | SORCS2 (G) | 0.950 | 0.928 | 0.041 | 0.954 | 0.931 | 0.006 | 0.0006 | 1.51 (1.19-1.92) |
rs10937823b | 4p16.1 | SORCS2 (C) | 0.949 | 0.912 | 0.001 | 0.954 | 0.930 | 0.004 | 1.4×10−5 | 1.67 (1.32-2.13) |
rs2291182 | 4q13.3 | C4orf35 (G) | 0.103 | 0.070 | 0.011 | 0.089 | 0.080 | 0.436 | 0.027 | 1.25 (1.02-1.52) |
rs7660807 | 4q13.3 | UNQ689 (G) | 0.111 | 0.070 | 0.001 | 0.096 | 0.084 | 0.266 | 0.004 | 1.33 (1.10-1.61) |
rs2162126a | 4q28.2 | PHF17 (C) | 0.884 | 0.840 | 0.004 | 0.156 | 0.148 | 0.5516 | 0.210 | ns |
rs3736456 | 4q35.1 | CYP4V2 (C) | 0.058 | 0.046 | 0.231 | not genotyped | ||||
rs437179 | 6p21.32 | SKIV2L (C) | 0.747 | 0.700 | 0.018 | 0.745 | 0.714 | 0.053 | 0.003 | 1.21 (1.07-1.36) |
rs13218303 | 6q24.3 | GRM1 (A) | 0.148 | 0.122 | 0.082 | not genotyped | ||||
rs17350383a | 7p21.1 | HDAC9 (T) | 0.181 | 0.161 | 0.218 | not genotyped | ||||
rs7812884 | 8p23.2 | CSMD1 (A) | 0.078 | 0.062 | 0.174 | not genotyped | ||||
rs2255317a | 8q22.2 | MATN2 (C) | 0.898 | 0.874 | 0.095 | not genotyped | ||||
rs942518 | 9q32 | DFNB31 (G) | 0.117 | 0.088 | 0.035 | 0.106 | 0.073 | 0.001 | 0.0001 | 1.44 (1.20-1.74) |
rs17477151 | 11p12 | NGL1 (G) | 0.927 | 0.899 | 0.027 | 0.926 | 0.916 | 0.285 | 0.030 | 1.26 (1.03-1.55) |
rs11021955 | 11p15.3 | GALNTL4 (C) | 0.898 | 0.855 | 0.003 | 0.883 | 0.860 | 0.059 | 0.001 | 1.33 (1.12-1.56) |
rs7933829 | 11q24.3 | C11orf44 (C) | 0.819 | 0.762 | 0.002 | 0.779 | 0.769 | 0.538 | 0.023 | 1.18 (1.03-1.33) |
rs9315885a | 13q14.11 | DGKH (T) | 0.737 | 0.680 | 0.005 | 0.701 | 0.654 | 0.006 | 0.0001 | 1.26 (1.12-1.42) |
rs1012053a | 13q14.11 | DGKH (A) | 0.899 | 0.843 | 0.0002 | 0.882 | 0.826 | 1.5 × 10−5 | 1.5 × 10−8 | 1.59 (1.35-1.87) |
rs1170191 | 13q14.11 | DGKH (G) | 0.868 | 0.820 | 0.003 | 0.849 | 0.800 | 0.0003 | 3.7 × 10−6 | 1.42 (1.23-1.65) |
rs9513877 | 13q33.1 | VGCNL1 (G) | 0.676 | 0.601 | 0.0005 | 0.643 | 0.602 | 0.021 | 8.1 × 10−5 | 1.26 (1.12-1.41) |
rs17125698a | 14q32.11 | CHES1 (C) | 0.858 | 0.821 | 0.028 | 0.868 | 0.843 | 0.049 | 0.003 | 1.26 (1.08-1.47) |
rs1818290a | 16p13.2 | A2BP1 (G) | 0.014 | 0.010 | 0.657 | not genotyped | ||||
rs7204975a | 16p13.2 | A2BP1 (C) | 0.886 | 0.836 | 0.001 | 0.857 | 0.851 | 0.542 | 0.533 | ns |
rs10500336 | 16p13.3 | A2BP1 (G) | 0.146 | 0.110 | 0.018 | 0.142 | 0.130 | 0.380 | 0.022 | 1.20 (1.02-1.41) |
rs4398100 | 16q23.2 | PLCG2 (C) | 0.834 | 0.802 | 0.069 | 0.851 | 0.829 | 0.106 | 0.014 | 1.20 (1.04-1.39) |
rs2360111 | 17p13.1 | NXN (C) | 0.629 | 0.554 | 0.0007 | 0.592 | 0.556 | 0.048 | 0.0003 | 1.23 (1.10-1.37) |
rs7212506 | 17q24.3 | ABCA6 (C) | 0.061 | 0.049 | 0.236 | not genotyped | ||||
rs6501822a | 1725.1 | LLGL2 (G) | 0.918 | 0.901 | 0.0192 | not genotyped | ||||
rs12608087 | 18q11.2 | LAMA3 (C) | 0.935 | 0.905 | 0.011 | 0.920 | 0.912 | 0.439 | 0.030 | 1.25 (1.02-1.52) |
rs335929 | 18q11.2 | AQP4 (C) | 0.225 | 0.179 | 0.010 | 0.204 | 0.097 | 0.097 | 0.004 | 1.23 (1.07-1.41) |
rs4813030c | 20p13 | PSMF1 (C) | 0.829 | 0.777 | 0.004 | 0.807 | 0.798 | 0.545 | 0.023 | 1.18 (1.03-1.35) |
Did not meet all allele frequency, p-value, or OR thresholds in both pooled samples
SNPs are in strong linkage disequilibrium: D' = 0.99, r2 = 0.96
SNP is not in HWE