. Author manuscript; available in PMC: 2008 Sep 1.

Published in final edited form as: J Pharmacol Exp Ther. 2008 Apr 16;326(1):196–208. doi: 10.1124/jpet.108.137455

TABLE 1. Detection of curcumin and TC in plasma and brain after multiple dosing routes.

These data showed brain and plasma levels of curcumin or TC 4 h after administration (by gavage, i.p., and i.m.). The lower limits of detection for curcumin were 35 ng/ml in plasma and 100 ng/g wet tissue in brain, and for TC they were 8 ng/ml in plasma and 250 ng/g wet tissue in brain. Data are presented as mean ± S.D.

Parent Compound (PC)	Route	Plasma	Plasma	Brain	Brain	Brain-to-Plasma Ratio (PC)
		µg/ml	µM	µg/g tissue	µM
Vehicle	i.m.	N.D.	N.D.	N.D.	N.D.	N.D.
Curc	gav	N.D.	N.D.	0.519 ± 0.098a	1.412	N.D.
Curc	i.p.	0.127 ± 0.035a^a	0.345	0.739 ± 0.019b	2.010	5.85
Curc	i.m.	0.238 ± 0.048b	0.647	1.162 ± 0.004c	3.157	4.88
Vehicle	i.m.	N.D.	N.D.	N.D.	N.D.	N.D.
TC	gav	N.D.	N.D.	0.274 ± 0.015d	0.736	N.D.
TC	i.p.	0.847 ± 0.019c	2.302	0.765 ± 0.023b	2.056	0.90
TC	i.m.	0.971 ± 0.092c	2.639	2.234 ± 0.163e	6.007	2.28

N.D., not detectable.

Different letters represent statistical differences of means from each other between treatments within route of administration or between routes within treatments; P < 0.05.