Table 2.

Linear Regression Models of demographic variables for (A) imaging features and (B) vascular risk factors.

	Brain Atrophy			Log (Ventricular Volume)			Log (Volume of White Matter Hyperintensity)
	Estimate	SE	p	Estimate	SE	p	Estimate	SE	p
A. Imaging Features
Intercept	−326.506	28.146	<0.001	−10.1139	1.2609	<0.001	−7.7731	1.4610	<0.001
Age	3.397	0.215	<0.001	0.0310	0.0018	<0.001	0.0381	0.0022	<0.001
Male Gender	6.176	4.368	0.157	0.1163	0.0335	<0.001	0.0448	0.0381	0.239
African-American Race	17.569	3.567	<0.001	−0.0811	0.0306	0.008	0.2058	0.0351	<0.001
Log (Brain Volume)/Log(TIV)/TIV*	0.289	0.017	<0.001	1.5416	0.1721	<0.001	1.0318	0.1992	<0.001
B. Vascular Risk Factors†
Hypertension severity	4.909	1.372	<0.001	0.0251	0.0099	0.011	0.0690	0.0125	<0.001
Log(serum glucose)	29.03	6.487	<0.001	0.1875	0.0558	<0.001	0.1350	0.0676	0.046
Serum homocysteine	2.573	0.557	<0.001	0.0107	0.0039	0.007	0.0167	0.0063	0.008
Log(pack-years smoking)	0.999	1.035	0.334	0.0143	0.0079	0.071	0.0282	0.0100	0.005
Total Cholesterol	−0.030	0.042	0.478	0.0003	0.0003	0.314	−0.0011	0.0004	0.007
High-density Lipoproteins	0.147	0.093	0.114	0.0006	0.0007	0.405	−0.0014	0.0009	0.111
Calculated Low-density Lipoproteins	−0.064	0.044	0.143	0.0000	0.0003	0.927	−0.0011	0.0004	0.014
Log(triglycerides)	3.449	3.194	0.280	0.0749	0.0257	0.004	0.0547	0.0287	0.056

^*TIV: Total Intracranial Volume

^†Risk factor models control for age at time of MR exam, gender, race, and total intracranial volume (for BA and VV) or brain volume (for WMH)