. Author manuscript; available in PMC: 2009 Aug 15.

Published in final edited form as: J Neurol Sci. 2008 Apr 28;271(1-2):53–60. doi: 10.1016/j.jns.2008.03.009

Table 5.

Race and Sex stratified logistic regression models of elevated UACR

	Model 1^a			Model 2^b			Model 3^c
	OR	95% CI		OR	95% CI		OR	95% CI
Race
Brain Atrophy
White	1.381	0.662	2.882	1.268	0.616	2.610	1.201	0.583	2.472
Black	2.432^*	1.549	3.818	2.286^*	1.396	3.745	2.106^*	1.281	3.461

White Matter Hyperintensities
White	3.290^*	1.524	7.105	3.388^*	1.563	7.346	3.314^*	1.499	7.325
Black	2.110^*	1.371	3.245	1.650⁺	1.009	2.698	1.605	0.973	2.648

Ventricular Volume
White	2.142⁺	1.045	4.391	1.970	0.935	4.150	1.845	0.880	3.868
Black	1.557	0.968	2.502	1.358	0.805	2.293	1.359	0.805	2.297

Sex
Brain Atrophy
Women	2.138^*	1.276	3.582	1.902⁺	1.093	3.312	1.760⁺	1.001	3.096
Men	1.925⁺	1.080	3.431	1.545	0.832	2.872	1.441	0.776	2.674

White Matter Hyperintensities
Women	2.171^*	1.308	3.603	2.054^*	1.198	3.522	2.096^*	1.215	3.614
Men	2.776^*	1.509	5.104	2.019⁺	1.016	4.012	1.950	0.965	3.941

Ventricular Volume
Women	1.581	0.928	2.693	1.226	0.695	2.164	1.168	0.668	2.041
Men	1.795	0.986	3.268	1.720	0.900	3.288	1.684	0.875	3.239

Model 1: Adjusted for age, race, sex, and TIV/logTIV/LogBrain.

Model 2: Included variables in model 1 plus log(glucose) and hypertension severity.

Model 3: Included variables in model 2 plus log(pack-years) and homocysteine.

⁺

p-value < 0.05

p-value < 0.01

BA, VV and WMH classified using the upper quartile of the residual values from models adjusting for age, race (not in models stratified by race), sex (not in models stratified by sex), and brain size (TIV for BA, log(TIV) for VV, and log(brain volume) for WMH).

UACR classified using clinical definition of > 20 for men and > 30 for women.