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Schematic representation of the male hypothalamic-pituitary-gonadal axis and the major hormones involved. Hypothalamic production of gonadotropin-releasing hormone (GnRH) stimulates anterior pituitary gland production of gonadotropins, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Testicular response to LH induces synthesis and release of testosterone from Leydig cells; FSH acts on Sertoli cells to stimulate inhibin production and support spermatogenesis
