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Effect of haloperidol, a DA receptor antagonist, on MnCl2-induced LHRH release (A) and NOS activity (B) from MBH in vitro. Note that the haloperidol blocked both of the actions induced by MnCl2. *p < 0.05 and **p < 0.01 versus control (open bars). Values represent mean ± SEM. The − or + symbols indicate the absence or presence of MnCl2 and haloperidol in the incubation medium.
