FIG. 2.

Effect of CYP2E1 expression on ovotoxicity with VCD. Ovaries from PND4 CYP2E1+/+ and −/− mice were incubated with control medium or increasing concentrations of VCD (5–30μM) for 15 days. Following incubation, ovaries were collected and processed for histological evaluation as described in the Materials and Methods section. (A) Primordial and (B) small primary follicles were classified and counted. Values are mean ± SE total follicles counted per ovary, n = 4–9; values with different letters are significantly different at p < 0.05.