Table V.
Association of CYP1B1 polymorphisms with disease aggressiveness in Hispanic and non-Hispanic Caucasians
| SNP | Genotype | Hispanic Caucasians |
Non-Hispanic Caucasians |
||||||||||
| High grade (n = 59), n (%) | Low grade (n = 61), n (%) | ORa | 95% CI | P | Trend P value | High grade (n = 149), n (%) | Low grade (n = 215), n (%) | ORa | 95% CI | P | Trend P value | ||
| rs2567206 | C/C | 36 (61) | 27 (44) | 1.00 | — | 0.27 | 66 (44) | 125 (58) | 1.00 | — | 0.002 | ||
| T/T | 5 (8) | 3 (5) | 1.24 | 0.26–5.75 | 0.78 | 20 (13) | 12 (6) | 3.14 | 1.44–6.84 | 0.004 | |||
| C/T | 18 (31) | 31 (51) | 0.44 | 0.20–0.97 | 0.04 | 63 (43) | 78 (36) | 1.52 | 0.97–2.38 | 0.07 | |||
| T/T + C/T | 0.52 | 0.25–1.08 | 0.08 | 1.74 | 1.14–2.66 | 0.01 | |||||||
| rs2551188 | G/G | 33 (56) | 27 (44) | 1.00 | — | 0.50 | 64 (43) | 125 (58) | 1.00 | — | 0.002 | ||
| A/A | 5 (8) | 3 (5) | 1.35 | 0.29–6.29 | 0.70 | 19 (13) | 12 (6) | 3.08 | 1.40–6.75 | 0.005 | |||
| A/G | 21 (36) | 31 (51) | 0.57 | 0.26–1.22 | 0.14 | 66 (44) | 78 (36) | 1.64 | 1.05–2.57 | 0.03 | |||
| A/A + A/G | 0.64 | 0.31–1.33 | 0.23 | 1.84 | 1.20–2.81 | 0.005 | |||||||
| rs2617266 | C/C | 35 (59) | 28 (46) | 1.00 | — | 0.41 | 64 (43) | 126 (59) | 1.00 | — | 0.001 | ||
| T/T | 5 (8) | 3 (5) | 1.32 | 0.29–6.13 | 0.72 | 19 (13) | 11 (5) | 3.38 | 1.51–7.57 | 0.003 | |||
| C/T | 19 (33) | 30 (49) | 0.52 | 0.24–1.12 | 0.09 | 66 (44) | 78 (36) | 1.66 | 1.06–2.59 | 0.03 | |||
| T/T + C/T | 0.59 | 0.28–1.24 | 0.16 | 1.87 | 1.22–2.86 | 0.004 | |||||||
| rs10012 | C/C | 33 (56) | 26 (43) | 1.00 | — | 0.40 | 64 (43) | 125 (58) | 1.00 | — | 0.002 | ||
| G/G | 5 (8) | 3 (5) | 1.30 | 0.28–6.05 | 0.74 | 19 (13) | 13 (6) | 2.85 | 1.32–6.15 | 0.008 | |||
| C/G | 21 (36) | 32 (52) | 0.53 | 0.24–1.13 | 0.10 | 66 (44) | 77 (36) | 1.66 | 1.06–2.61 | 0.03 | |||
| G/G + C/G | 0.59 | 0.29–1.24 | 0.16 | 1.84 | 1.20–2.81 | 0.005 | |||||||
| rs1056836 | C/C | 35 (65) | 34 (61) | 1.00 | — | 0.57 | 58 (39) | 60 (29) | 1.00 | — | 0.01 | ||
| G/G | 1 (2) | 2 (3) | 0.47 | 0.04–5.68 | 0.55 | 21 (14) | 49 (23) | 0.45 | 0.24–0.84 | 0.01 | |||
| C/G | 18 (33) | 20 (36) | 0.87 | 0.39–1.94 | 0.73 | 69 (47) | 102 (48) | 0.71 | 0.44–1.14 | 0.16 | |||
| G/G + C/G | 0.83 | 0.38–1.83 | 0.65 | 0.62 | 0.40–0.98 | 0.04 | |||||||
| rs1800440 | A/A | 38 (66) | 41 (71) | 1.00 | — | 0.26 | 85 (63) | 129 (66) | 1.00 | — | 0.97 | ||
| G/G | 3 (5) | 0 (0) | ND | ND | ND | 4 (3) | 10 (5) | 0.59 | 0.18–1.96 | 0.39 | |||
| A/G | 17 (29) | 17 (29) | 1.12 | 0.49–2.54 | 0.79 | 46 (34) | 58 (29) | 1.20 | 0.75–1.94 | 0.45 | |||
| G/G + A/G | 1.31 | 0.59–2.92 | 0.51 | 1.11 | 0.70–1.76 | 0.65 | |||||||
High grade includes case with Gleason score ≥7, Low grade includes case with Gleason score <7, ND, not determined.
a
Adjusted for age. Significant results are shown in bold.