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. 2008 Sep 15;3(9):e3211. doi: 10.1371/journal.pone.0003211

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Allard et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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HepG2 cells were cultured in media supplemented with human sera for 48 h (A) shows relative changes in PGC-1α mRNA in cells cultured with serum collected after 3 months on diets compared to cells cultured with serum collected at baseline. (B) Shows the average relative change in PGC-1α mRNA expression for each diet group. For C, CR and CREX n = 7, 8 and 9, respectively. * p = 0.032.