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. 2008 Sep 15;3(9):e3212. doi: 10.1371/journal.pone.0003212

Figure 4. ES-derived HOXB4-expressing HPCs induce immunological tolerance to donor type cardiac allografts.

Figure 4

A) Treatment protocol: MRL recipient mice were transplanted HPCs 14 days prior to transplantation of cardiac allografts which was performed between days 0 and 7. Cardiac function and survival were monitored by daily abdominal palpations. B) Graft survival: Chimeric MRL recipient mice tolerated donor type cardiac allografts, but not Balb/c third party allografts. Non-chimeric MRL mice acutely rejected allografts within 13 days. Syngeneic grafts were additionally used as controls.