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. 2008 May 14;3(5):e2179. doi: 10.1371/journal.pone.0002179

Table 2. SSTF Genes (1691 genes; 3574 probe sets) Activated by Lbx1 in the Neural Tube (4.1%).

Classa #b SSTFc NTd UCRe Heterof (n = 3) Mutantf (n = 3) Fold Δg
(Highest) Average Signal of PS (Lowest)
1. Basic (177 genes; 362 probe set) 5% activated
bZIP 1 Mafa + 487± 115 48± 12 −10.2
2 Mafb da 271± 33 64± 8 −4.2 −2.6
3 Jun + 255± 52 129± 13 −2.0 −2.1
4 Jundm2 ns 75 442± 12 313± 23 −1.4
bHLH 5 Neurog3 vz 25±4 12±5 −2.1 −1.1*†
6 Id4 d + 7606±306 3816±930 −2.0 −1.9 −1.9 −2.5
7 Id3 d 324±42 191±58 −1.7
8 Hes5 vz 369±62 289±47 −1.3* −1.5*
2. Zinc-coordinated (749 genes; 1627 probe sets) 3% activated
C4 9 Nr2f2 + 81/+ 833±23 412±66 −2.0 −2.4 −2.0 −2.4
10 Trps1 d, vz + 158±32 113±19 −1.4* −1.2* −1.2* −1.8
11 Sall3 da,vz 28 777±184 77±16 −10.1 −4.9
12 Sall4 + 76 95±28 26±8 −3.7 −1.5*†
13 Zic5 da 63 477±113 63±12 −7.6 −4.5 −1.8
14 Zic4 da 62/+ 414±157 105±18 −3.9 −3.4
15 Zic3 da 95 1625±212 601±34 −2.7 −3.2
16 Zic2 da 63/+ 327±71 110±7 −3.0
17 Zic1 da 62 14774±804 6851±417 −2.2 −3.8
18 Wt1 + 35±18 10±3 −3.5*†
19 Zfp804a nd 584±72 195±19 −3.0 −1.6*†
20 Klf5 ns 33±6 12±2 −2.9 −1.8† −1.5*†
21 Zfpm2 pm 21/+ 199±54 97±16 −2.1 −1.4
22 Ikzf4 + 197± 12 142± 16 −1.4 −2.2 −1.1*†
23 Bcl11a pm 13/+ 5272±514 2881±141 −1.8 −1.9 −2.1
24 Zcchc11 nd 1899±34 1838±86 −1.0* −1.2* −1.8* −1.1*
25 Hivep2 vz 153±20 95±5 −1.6 −1.8
26 Rest da 187±9 108±13 −1.7 −1.4* −1.1*† −1.0*†
27 Zfp704 nd 361±52 226±15 −1.6 −1.2*†
28 Zfp467 ns 227±21 138±9 −1.6 −1.7 −1.3*
29 Zfp775 nd 208±29 142±11 −1.5
30 B930008K04Rik nd 62±5 43±6 −1.4
31 Zfp784 nd 54±5 38±2 −1.4
CCHC 32 Zcchc12 pm 337±71 151±36 −2.2
CXXC 33 Cxxc5 nd 3114±127 1975±7 −1.6 −1.4
34 Cxxc4 nd 1398±118 1105±129 −1.3 −1.4 1.1*†
3. Helix-turn-helix (512 genes; 1026 probe sets) 5% activated
HD 35 Gbx1 da 1422± 288 67± 29 −21.2
36 Gbx2 da 86 3027±237 1216±169 −2.5
37 Lbx1 da 3374±137 331±7 −10.2 −7.6
38 Tshz2 d,pm 76 1372±238 209±24 −6.6 −8.1 −5.3
39 Lhx2 d,pm 104 240±179 34±3 −7.0*
40 Lhx1 pm 50/+ 5763±271 2575±1214 −2.2 −2.4
41 Pknox2 d, pm 1865±198 437±43 −4.3 −2.5
42 Satb2 + + 216±28 70±12 −3.1 −1.0*
43 Lmx1b da + 601± 135 286± 50 −2.1 −1.1*†
44 Nkx6-1 vz,svz 31 81±27 47±12 −1.7*
45 Hoxa4 pm 56 149±15 99±4 −1.7* −1.5
46 Hoxb2 d,pm 82 2517±160 1526±130 −1.6
47 Hoxb8 d,pm 82 4850±249 3297±476 −1.5
48 Msx1 d,vz 77±14 46±7 −1.7 1.1*
49 Msx2 d,vz 14±1 10±2 −1.5
50 Zfhx1b d,svz 2/+ 853±100 519±90 −1.6 −1.8 −1.7* −1.2*†
51 Pax6 vz,da 83/+ 72±11 51±5 −1.4 1.0* −1.1*
52 Prrxl1 da 101/+
PD 53 Pax8 pm 861±224 84±24 −10.2
54 Pax5 + 90 350±45 209± 24 −1.7 1.2*† 1.0*†
FH 55 E2F8 nd 53±11 33±7 −1.6 1.0*†
TC 56 Ets2 d 346±90 140±22 −2.5
57 Elk3 + 103±29 48±14 −2.1 1.1* −1.3*
58 Etv5 d 46±5 23±4 −2.0 1.4* 1.0*†
WH 59 Depdc1a nd 31±3 16±3 −2.0
60 Cdc6 nd 36±9 20±4 −1.8
61 Rfx4 d 524±50 323±86 −1.6 1.1*†
62 Myst4 d 1420±39 992±80 −1.4 −1.1*†
63 Rfxdc2 d 2433±54 2177±121 −1.1 −1.1*† −1.6* 1.0*
4. ß-scaffold (116 genes; 281 probe sets) 2% activated
STAT 64 Stat1 ns 76±6 53±10 −1.4 −1.5* −1.3*
HMG 65 Sox13 pm 127±28 66±7 −1.9
5. Other (138 genes; 279 probe sets) 4% activated
66 Dmrt3 pm 148 63±31 12±1 −5.5
67 Lbxcor1 pm + 25659+ 1614 6284± 653 −4.1
68 Dmrtb1 nd 357±63 169±11 −2.1
69 Notch3 vz 282±82 143±23 −2.0 −1.3*
70 Notch2 vz 266±32 158±33 −1.7 1.0*†
71 Obfc2a nd 186±41 104±15 −1.8 −1.3* −1.5* −1.3*† 1.0*† 1.0*†
a–g

As in Table 1.