Table 2. SSTF Genes (1691 genes; 3574 probe sets) Activated by Lbx1 in the Neural Tube (4.1%).
Classa | #b | SSTFc | NTd | UCRe | Heterof (n = 3) | Mutantf (n = 3) | Fold Δg | |||||
(Highest) | Average Signal of PS | (Lowest) | ||||||||||
1. Basic (177 genes; 362 probe set) 5% activated | ||||||||||||
bZIP | 1 | Mafa | + | 487± 115 | 48± 12 | −10.2 | ||||||
2 | Mafb | da | 271± 33 | 64± 8 | −4.2 | −2.6 | ||||||
3 | Jun | + | 255± 52 | 129± 13 | −2.0 | −2.1 | ||||||
4 | Jundm2 | ns | 75 | 442± 12 | 313± 23 | −1.4 | ||||||
bHLH | 5 | Neurog3 | vz | 25±4 | 12±5 | −2.1 | −1.1*† | |||||
6 | Id4 | d | + | 7606±306 | 3816±930 | −2.0 | −1.9 | −1.9 | −2.5 | |||
7 | Id3 | d | 324±42 | 191±58 | −1.7 | |||||||
8 | Hes5 | vz | 369±62 | 289±47 | −1.3* | −1.5* | ||||||
2. Zinc-coordinated (749 genes; 1627 probe sets) 3% activated | ||||||||||||
C4 | 9 | Nr2f2 | + | 81/+ | 833±23 | 412±66 | −2.0 | −2.4 | −2.0 | −2.4 | ||
10 | Trps1 | d, vz | + | 158±32 | 113±19 | −1.4* | −1.2* | −1.2* | −1.8 | |||
11 | Sall3 | da,vz | 28 | 777±184 | 77±16 | −10.1 | −4.9 | |||||
12 | Sall4 | + | 76 | 95±28 | 26±8 | −3.7 | −1.5*† | |||||
13 | Zic5 | da | 63 | 477±113 | 63±12 | −7.6 | −4.5 | −1.8 | ||||
14 | Zic4 | da | 62/+ | 414±157 | 105±18 | −3.9 | −3.4 | |||||
15 | Zic3 | da | 95 | 1625±212 | 601±34 | −2.7 | −3.2 | |||||
16 | Zic2 | da | 63/+ | 327±71 | 110±7 | −3.0 | ||||||
17 | Zic1 | da | 62 | 14774±804 | 6851±417 | −2.2 | −3.8 | |||||
18 | Wt1 | + | 35±18 | 10±3 | −3.5*† | |||||||
19 | Zfp804a | nd | 584±72 | 195±19 | −3.0 | −1.6*† | ||||||
20 | Klf5 | ns | 33±6 | 12±2 | −2.9 | −1.8† | −1.5*† | |||||
21 | Zfpm2 | pm | 21/+ | 199±54 | 97±16 | −2.1 | −1.4 | |||||
22 | Ikzf4 | + | 197± 12 | 142± 16 | −1.4 | −2.2 | −1.1*† | |||||
23 | Bcl11a | pm | 13/+ | 5272±514 | 2881±141 | −1.8 | −1.9 | −2.1 | ||||
24 | Zcchc11 | nd | 1899±34 | 1838±86 | −1.0* | −1.2* | −1.8* | −1.1* | ||||
25 | Hivep2 | vz | 153±20 | 95±5 | −1.6 | −1.8 | ||||||
26 | Rest | da | 187±9 | 108±13 | −1.7 | −1.4* | −1.1*† | −1.0*† | ||||
27 | Zfp704 | nd | 361±52 | 226±15 | −1.6 | −1.2*† | ||||||
28 | Zfp467 | ns | 227±21 | 138±9 | −1.6 | −1.7 | −1.3* | |||||
29 | Zfp775 | nd | 208±29 | 142±11 | −1.5 | |||||||
30 | B930008K04Rik | nd | 62±5 | 43±6 | −1.4 | |||||||
31 | Zfp784 | nd | 54±5 | 38±2 | −1.4 | |||||||
CCHC | 32 | Zcchc12 | pm | 337±71 | 151±36 | −2.2 | ||||||
CXXC | 33 | Cxxc5 | nd | 3114±127 | 1975±7 | −1.6 | −1.4 | |||||
34 | Cxxc4 | nd | 1398±118 | 1105±129 | −1.3 | −1.4 | 1.1*† | |||||
3. Helix-turn-helix (512 genes; 1026 probe sets) 5% activated | ||||||||||||
HD | 35 | Gbx1 | da | 1422± 288 | 67± 29 | −21.2 | ||||||
36 | Gbx2 | da | 86 | 3027±237 | 1216±169 | −2.5 | ||||||
37 | Lbx1 | da | 3374±137 | 331±7 | −10.2 | −7.6 | ||||||
38 | Tshz2 | d,pm | 76 | 1372±238 | 209±24 | −6.6 | −8.1 | −5.3 | ||||
39 | Lhx2 | d,pm | 104 | 240±179 | 34±3 | −7.0* | ||||||
40 | Lhx1 | pm | 50/+ | 5763±271 | 2575±1214 | −2.2 | −2.4 | |||||
41 | Pknox2 | d, pm | 1865±198 | 437±43 | −4.3 | −2.5 | ||||||
42 | Satb2 | + | + | 216±28 | 70±12 | −3.1 | −1.0* | |||||
43 | Lmx1b | da | + | 601± 135 | 286± 50 | −2.1 | −1.1*† | |||||
44 | Nkx6-1 | vz,svz | 31 | 81±27 | 47±12 | −1.7* | ||||||
45 | Hoxa4 | pm | 56 | 149±15 | 99±4 | −1.7* | −1.5 | |||||
46 | Hoxb2 | d,pm | 82 | 2517±160 | 1526±130 | −1.6 | ||||||
47 | Hoxb8 | d,pm | 82 | 4850±249 | 3297±476 | −1.5 | ||||||
48 | Msx1 | d,vz | 77±14 | 46±7 | −1.7 | 1.1* | ||||||
49 | Msx2 | d,vz | 14±1 | 10±2 | −1.5 | |||||||
50 | Zfhx1b | d,svz | 2/+ | 853±100 | 519±90 | −1.6 | −1.8 | −1.7* | −1.2*† | |||
51 | Pax6 | vz,da | 83/+ | 72±11 | 51±5 | −1.4 | 1.0* | −1.1* | ||||
52 | Prrxl1 | da | 101/+ | |||||||||
PD | 53 | Pax8 | pm | 861±224 | 84±24 | −10.2 | ||||||
54 | Pax5 | + | 90 | 350±45 | 209± 24 | −1.7 | 1.2*† | 1.0*† | ||||
FH | 55 | E2F8 | nd | 53±11 | 33±7 | −1.6 | 1.0*† | |||||
TC | 56 | Ets2 | d | 346±90 | 140±22 | −2.5 | ||||||
57 | Elk3 | + | 103±29 | 48±14 | −2.1 | 1.1* | −1.3* | |||||
58 | Etv5 | d | 46±5 | 23±4 | −2.0 | 1.4* | 1.0*† | |||||
WH | 59 | Depdc1a | nd | 31±3 | 16±3 | −2.0 | ||||||
60 | Cdc6 | nd | 36±9 | 20±4 | −1.8 | |||||||
61 | Rfx4 | d | 524±50 | 323±86 | −1.6 | 1.1*† | ||||||
62 | Myst4 | d | 1420±39 | 992±80 | −1.4 | −1.1*† | ||||||
63 | Rfxdc2 | d | 2433±54 | 2177±121 | −1.1 | −1.1*† | −1.6*† | 1.0*† | ||||
4. ß-scaffold (116 genes; 281 probe sets) 2% activated | ||||||||||||
STAT | 64 | Stat1 | ns | 76±6 | 53±10 | −1.4 | −1.5* | −1.3* | ||||
HMG | 65 | Sox13 | pm | 127±28 | 66±7 | −1.9 | ||||||
5. Other (138 genes; 279 probe sets) 4% activated | ||||||||||||
66 | Dmrt3 | pm | 148 | 63±31 | 12±1 | −5.5 | ||||||
67 | Lbxcor1 | pm | + | 25659+ 1614 | 6284± 653 | −4.1 | ||||||
68 | Dmrtb1 | nd | 357±63 | 169±11 | −2.1 | |||||||
69 | Notch3 | vz | 282±82 | 143±23 | −2.0 | −1.3* | ||||||
70 | Notch2 | vz | 266±32 | 158±33 | −1.7 | 1.0*† | ||||||
71 | Obfc2a | nd | 186±41 | 104±15 | −1.8 | −1.3* | −1.5* | −1.3*† | 1.0*† | 1.0*† |
As in Table 1.