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. Author manuscript; available in PMC: 2008 Sep 2.
Published in final edited form as: J Am Chem Soc. 2006 Apr 19;128(15):5049–5058. doi: 10.1021/ja0573054

Figure 11.

Figure 11

Transition state models via water-catalysis at neutral pH. Each model has two hydrogen bonds between the water oxygen and O1. Note the asymmetry in O-H-O interatomic radii and that placement is nearly identical for each proton shared.