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Inhibition of TCDD-induced P450 1A/B activity with cis-terpenones. HepG2 cells were co-treated with TCDD (1 nM) and cis-terpenones 1-3 and incubated for 24 h. The activity of P450 1A/B was determined with the EROD assay. Bars represent the mean ± SD of EROD activity at 590 nm in 4 replicates. The data are representative of three independent experiments. C: DMSO only. * P<0.05, ** P<0.001 compared to TCDD only with one way ANOVA and Dunnett’s test.
