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. Author manuscript; available in PMC: 2008 Sep 2.
Published in final edited form as: Biochemistry. 2007 May 31;46(25):7572–7580. doi: 10.1021/bi700227g

FIGURE 7.

FIGURE 7

Western analysis of inhibition of PR protein expression by agLNAs with different predicted thermal stabilities. Inhibition of PR by LNA PR10 (predicted Tm of 76°C), LNA PR3 (predicted Tm of 83°C), and LNA PR11 (predicted Tm of 91°C) shown at 25 nM (A) and at 50 nM (B). Percent inhibition of PR–B is relative to the average of noncomplementary LNAs LNAscr1 and LNAscr2. All agLNAs are complementary to −9 to +10 relative to the transcriptional start site of PRB. ni: no significant (<30%) inhibition.