Table 1. Multivariable proportional-hazard analysis of the risk of distant metastases as a first event in patients who did not receive chemotherapy (n=185).

Variable	Hazard ratio (95% CIa)	P-value
Age (per 10-year increment)	0.58 (0.39–0.87)	0.008
Lymph node status (per positive node)	1.16 (1.02–1.30)	0.02
Tumour diameter (per 10 cm)	1.15 (0.82–1.61)	0.42
Tumour grade
Grade 2 (vs grade 1)	2.76 (1.09–6.99)	0.03
Grade 3 (vs grade 1)	2.80 (1.07–7.33)	0.04
Vascular invasion
1–3 vessels (vs 0 vessels)	0.45 (0.11–1.90)	0.28
>3 vessels (vs 0 vessels)	2.14 (1.25–3.67)	0.006
Oestrogen receptor expression	1.02 (0.61–1.70)	0.95
Mastectomy (vs breast-conserving therapy)	1.92 (1.08–3.40)	0.03
Hormonal treatment (vs no hormonal treatment)	1.05 (0.40–2.79)	0.92
PRAME high expression (vs low expression)	2.26 (1.27–4.01)	0.006

^aCI denotes confidence interval.