Table 1. Analysis of correlation between clinicopathological parameters and relative MIER1α staining in breast carcinoma.
|
MIER1 expression:a tumor Allred score vs normal Allred score
|
|||||
|---|---|---|---|---|---|
| Parameters | Less than normal | Equal to normal | Greater than normal | Total | P-valueb |
| Age | |||||
| <50 | 6 (19.4) | 4 (12.9) | 21 (67.7) | 31 | |
| >=50 | 8 (10.1) | 16 (20.3) | 55 (69.6) | 79 | P=0.410 |
| Age | |||||
| <=44 | 5 (25.0) | 3 (15.0) | 12 (60.0) | 20 | |
| 44–64 | 4 (7.5) | 9 (17.0) | 40 (75.5) | 53 | |
| >=65 | 5 (13.9) | 8 (19.4) | 24 (66.7) | 37 | P=0.365 |
| Tumor size (TNM) | |||||
| T1 | 6 (10.2) | 11 (18.6) | 42 (71.2) | 59 | |
| T2 | 7 (16.7) | 6 (14.3) | 29 (69.0) | 42 | |
| T3 and T4 | 1 (11.1) | 3 (33.3) | 5 (55.6) | 9 | P=0.618 |
| Tumor size (categorical) | |||||
| <=2 cm | 6 (10.2) | 11 (18.6) | 42 (71.2) | 59 | |
| >2 cm | 8 (15.7) | 9 (17.6) | 34 (66.7) | 51 | P=0.693 |
| Lymph node involvement | |||||
| No | 6 (13.6) | 9 (20.5) | 28 (63.6) | 43 | |
| Yes | 4 (12.5) | 6 (18.8) | 22 (68.8) | 32 | P=0.957 |
| Lymph node status (TNM) | |||||
| N0 | 6 (13.6) | 9 (20.5) | 28 (63.6) | 43 | |
| N1 | 4 (16.0) | 5 (20.0) | 16 (64.0) | 25 | |
| N2 | 0 (0) | 0 (0) | 6 (100.0) | 6 | |
| N3 | 0 (0) | 0 (0) | 1 (100.0) | 1 | P=0.941 |
| Grade c | |||||
| 1 | 6 (20.0) | 8 (26.7) | 16 (53.3) | 30 | |
| 2 | 5 (11.9) | 8 (19.1) | 29 (69.0) | 42 | |
| 3 | 3 (8.1) | 4 (10.8) | 30 (81.1) | 37 | P=0.217 |
| Stage d | |||||
| I | 1 (4.0) | 6 (24.0) | 18 (72.0) | 25 | |
| II | 9 (23.1) | 4 (10.3) | 26 (66.6) | 39 | |
| III | 0 (0) | 3 (27.3) | 8 (72.7) | 11 | |
| IV | 0 | 0 | 0 | 0 | P=0.082 |
| ER | |||||
| Negative | 2 (12.5) | 2 (12.5) | 12 (75.0) | 16 | |
| Positive | 10 (11.2) | 16 (18.0) | 63 (70.8) | 89 | P=0.891 |
| PR | |||||
| Negative | 3 (10.8) | 2 (7.1) | 23 (82.1) | 28 | |
| Positive | 9 (11.8) | 15 (19.7) | 52 (68.4) | 76 | P=0.300 |
| HER2/neu status | |||||
| Negative | 10 (13.5) | 15 (20.3) | 49 (66.2) | 74 | |
| Positive | 1 (6.7) | 0 (0) | 14 (93.3) | 15 | P=0.086 |
a
Values are listed as number of subjects, with percentage listed in brackets.
b
P-value; χ2 analysis (Pearson's test, two-tailed, 95% CI), statistical significance is assumed when P<0.05.
c
Modified Scarff–Bloom–Richardson grading system.
d
FIGO staging system.