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. 2008 Jul 29;99(4):647–654. doi: 10.1038/sj.bjc.6604521

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Copyright © 2008 Cancer Research UK

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Invasive foci formation and invasion depth of cancer cells were inhibited by EGCG. (A) On top of collagen gels ( × 200 magnification) EGCG or 5-aza-dC significantly blocked cancer invasion in HSC3 cells by decreasing the mean number of invasive foci/field by t-test. Results are shown as the mean number of invasive foci ±1 s.d. in five randomly selected fields (6 days). (B) Focal plane located 200 μm below the top of collagen ( × 100 magnification). 6 days after addition of HSC3 cells to gels, the depths of cell invasion of cells that had invaded the gel were significantly blocked in cells treated with EGCG. Similar results were observed with HSC4 cell line (not shown).