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. 2008 Jun 16;155(1):34–43. doi: 10.1038/bjp.2008.235

Figure 1.

Figure 1

Isolation of TTXR current using a holding potential (Vh) of −50 mV. (a) Sodium current recorded from a cell containing both TTXS and TTXR sodium currents is shown. When this cell is held at a Vh of −50 mV, the faster TTXS component is inactivated leaving the isolated TTXR current. (b) Sodium current recorded in a cell that expressed purely TTX-sensitive (TTXS) currents is shown. When a Vh of −50 mV is used, no current is observed as, at this potential, the TTXS sodium channels have undergone voltage-dependent inactivation. The protocol used for all recordings is shown underneath.