TABLE 3.
Polymorphic and monomorphic residue positions in three-Angstrom patches on HLA-DQA1 alleles*
Class II Locus | Sequence position | Molecular location | Surface exposure | 3.0 Angstrom patches | ||||||
---|---|---|---|---|---|---|---|---|---|---|
DQA | 2 | Side | ++ | 1 | 2 | 3 | ||||
DQA | 18 | Side | ++ | 17 | 18 | 19 | B7 | |||
DQA | 21 | Side | + | 20 | 21 | 22 | ||||
DQA | 25 | Side | ± | 14 | 24 | 25 | 26 | 27 | 37 | P5 |
DQA | 40 | Side | + | 39 | 40 | 41 | ||||
DQA | 41 | Side | ++ | 38 | 40 | 41 | 42 | |||
DQA | 44 | Side | ++ | 43 | 44 | 45 | ||||
DQA | 45 | Side | + | 36 | 44 | 45 | 46 | |||
DQA | 47 | Side | + | 34 | 46 | 47 | 48 | |||
DQA | 48 | Side | + | 47 | 48 | 49 | 51 | |||
DQA | 50 | Side | ++ | 49 | 50 | 51 | ||||
DQA | 51 | Underside | + | 48 | 50 | 51 | 52 | 53 | ||
DQA | 52 | Side | + | 49 | 51 | 52 | 53 | |||
DQA | 53 | Top | ++ | 51 | 52 | 53 | 54 | |||
DQA | 54 | Top | ++ | 51 | 53 | 54 | 55 | |||
DQA | 55 | Top | + | 54 | 55 | 56 | ||||
DQA | 56 | Top | ++ | 53 | 55 | 56 | 57 | |||
DQA | 59 | Top | + | 58 | 59 | 60 | 61 | 62 | ||
DQA | 61 | Top | ++ | 58 | 59 | 60 | 61 | 62 | 65 | |
DQA | 64 | Top | ++ | 60 | 63 | 64 | 65 | |||
DQA | 66 | Top | + | 62 | 65 | 66 | 67 | 70 | ||
DQA | 69 | Top | ± | 65 | 68 | 69 | 70 | |||
DQA | 75 | Top | ++ | 74 | 75 | 76 | 79 | |||
DQA | 76 | Top | ± | 72 | 75 | 76 | 77 | 80 | ||
DQA | 79 | Top | ++ | 75 | 78 | 79 | 80 | B32 | ||
DQA | 80 | Side | ± | 75 | 79 | 80 | 81 | |||
DQA | 107 | Side | + | 97 | 106 | 107 | 108 | |||
DQA | 129 | Side | ++ | 126 | 128 | 129 | 130 | |||
DQA | 130 | Side | + | 129 | 130 | 131 | ||||
DQA | 138 | Side | + | 137 | 138 | 139 | 141 | |||
DQA | 139 | Side | + | 33 | 138 | 139 | 140 | 141 | ||
DQA | 153 | Side | + | 136 | 152 | 153 | 154 | B150 | ||
DQA | 156 | Bottom | + | 106 | 155 | 156 | 157 | |||
DQA | 160 | Bottom | + | 159 | 160 | 161 | ||||
DQA | 161 | Bottom | ++ | 160 | 161 | 162 | ||||
DQA | 163 | Bottom | + | 127 | 162 | 163 | 164 | |||
DQA | 175 | Side | ++ | 174 | 175 | 176 |
Polymorphic positions are marked in bold, underlined font.