TABLE 7.
Example of an HLAMatchmaker Analysis to Determine HLA-DR and HLA-DQ Compatibility at the Eplet Level
| Mismatched Antigen | Number of mm Eplets | Mismatched Eplets | Same 2-Digit Allele | Number of mm Eplets | Mismatched Eplets |
|---|---|---|---|---|---|
| DRB1*0101 (DR1) | 8 | 12LKF, 14FEH, 25HRL, 26RL, 31QCIY, 67LR, 71QRA, 74QRAA | DRB1*1102 | 2 | 67IE, 71DEA |
| DRB1*0301 (DR3) | 3 | 25HRY, 31YYFH, 73GRDN | DRB1*1103 | 2 | 67IE, 71DEA |
| DRB1*0401 (DR4) | 6 | 12VKH, 34HQ, 47DYR, 71QKA, 96YL, 180LT | DRB1*1104 | 0 | |
| DRB1*0701 (DR7) | 9 | 4Q, 14YKH, 25HQF, 31QLFY, 59AES, 67IR, 71DRG, 98ES, 180VM | DRB1*1105 | 2 | 12STG, 14GEH |
| DRB1*0802 (DR8) | 5 | 12STG, 14GEY, 25YRF, 47DYR, 73ALDT | DRB1*1106 | 1 | 81HA |
| DRB1*0901 (DR9) | 12 | 4Q, 12DKF, 14FEH, 25HRY, 31QGIY, 59AES, 70FRRA, 71RRA, 73AEDT, 74RRAE, 98ES, 180VM | |||
| DRB1*1001 (DR10) | 11 | 12VKF, 14FEH, 25HRL, 26RL, 31ERVH, 40EYD, 67LR, 70LRRA, 71RRA, 74RRAA, 180VM | DRB1*1502 | 0 | |
| DRB1*1201 (DR12) | 10 | 12STG, 14GEY, 25YRL, 26RL, 31YHFH, 47EFR, 59AES, 67IR, 70IDRA, 81HA | DRB1*1503 | 1 | 31QHFY |
| DRB1*1301 (DR13) | 3 | 31YYFH, 67IE, 71DEA | DRB1*1504 | 1 | 67FA |
| DRB1*1401 (DR14) | 9 | 31 YYFH, 47DYR, 57AA, 67LR, 70LRRA, 71RRA, 73AEDT, 74RRAE, 112Y | |||
| DRB1*1601 (DR16) | 1 | 47DYR | |||
| DRB1*1602 (DR16) | 3 | 47DYR, 67LR, 70LDRA | |||
| DRB3*0101 (DR52a) | 7 | 12RKS, 25HRY, 31LYFH, 47DYR, 59AES, 73GRDN, 183A | DRB3*0201 | 0 | |
| DRB3*0301 (DR52c) | 2 | 31LYFH, 59AES | DRB3*0203 | 0 | |
| DRB4*0101 (DR53) | 16 | 4Q, 16HLW, 25HWN, 31QYIY, 40IYN, 44NL, 48YQ, 67LR, 70LRRA, 71RRA, 73AEDT, 74RRAE, 81YV, 96QM, 180MM, 187Q | DRB3*0204 | 1 | 73GRDN |
| DRB5*0202 (DR51b) | 3 | 6C, 31QGIY, 81HA | DRB5*0102
DRB5*0103 DRB5*0104 DRB5*0105 |
1
2 1 0 |
31QGIY
31QGIY, 67FT 73ALDT |
| DQB1*0201 (DQ2) | 8 | 30SIV, 45GE, 52LL, 56LPA, 57PA, 66DI, 70RK, 77DR | DQB1*0302 (DQ8) | 3 | 56PPA, 57PA, 185I |
| DQB1*0401 (DQ4) | 7 | 23L, 26G, 55PRL, 66DI, 70ED, 74SV, 185I | DQB1*0303 (DQ9) | 1 | 185I |
| DQB1*0501 (DQ5) | 10 | 14GL, 26G, 30HYV, 57PV, 70GA, 74SV, 77DR, 87AY, 116I, 125SQ | DQB1*0304
DQB1*0305 DQB1*0601 DQB1*0603 DQB1*0604 DQB1*0609 |
2
4 4 1 4 3 |
56PPA, 57PA
26G, 56PPA, 57PA, 185I 3P, 30YDV, 66DI, 67DIT 30HYA 30HYA, 57PV, 87GY, 130Q 57PV, 87GY, 130Q |
| DQA1*0201 | 7 | 25FT, 47EKL, 48LF, 52FHR, 76IL, 79IRS, 175E | DQA1*0101 | 1 | 47ERW |
| DQA1*0301 | 7 | 25YS, 47EQL, 48LF, 52FRR, 75IVR, 79IRS, 175E | DQA1*0103 | 3 | 25FT, 40EK, 129HA |
| DQA1*0401 | 4 | 69T, 76IL, 79IRS, 175E | DQA1*0104 | 2 | 2G, 47ERW |
| DQA1*0601 | 5 | 25FT, 69T, 76IL, 79IRS, 175E | DQA1*0502
DQA1*0503 |
0
1 |
160SE |
Recipient Type: DRB1*1101, 1501; DRB3*0202; DRB5*0101; DQA1*0102, 0501; DQB1*0301, 0602