Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1986 Feb;57(2):688–692. doi: 10.1128/jvi.57.2.688-692.1986

Characterization of a new type of human papillomavirus found in a lesion of Bowen's disease of the skin.

M Kawashima, S Jablonska, M Favre, S Obalek, O Croissant, G Orth
PMCID: PMC252786  PMID: 3003400

Abstract

The genome of a human papillomavirus (HPV) found in a patient with Bowen's disease of the skin was molecularly cloned. Blot hybridization experiments, performed under stringent conditions, revealed no cross-hybridization between this HPV DNA and the other known HPV DNAs, showing that this HPV represents a new type, tentatively named HPV34. In relaxed hybridization conditions, the highest cross-hybridization was observed with HPV16 DNA. The physical map of HPV34 DNA was aligned with the genetic map of HPV16 DNA by heteroduplex mapping. HPV34 was not detected in 12 additional patients with Bowen's disease of the skin, but a closely related HPV DNA was found in one patient with penile Bowenoid papulosis.

Full text

PDF
688

Images in this article

689Image
on p.689
689Image
on p.689
690Image
on p.690
691Image
on p.691

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boshart M., Gissmann L., Ikenberg H., Kleinheinz A., Scheurlen W., zur Hausen H. A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J. 1984 May;3(5):1151–1157. doi: 10.1002/j.1460-2075.1984.tb01944.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Croissant O., Testanière V., Orth G. Mise en évidence et localisation de régions conservées dans les génomes du papillomavirus human 1 a et du papillomavirus bovin 1 par analyse d'"hétéroduplex" au microscope électronique. C R Seances Acad Sci III. 1982 Mar 22;294(12):581–586. [PubMed] [Google Scholar]
  3. Crum C. P., Ikenberg H., Richart R. M., Gissman L. Human papillomavirus type 16 and early cervical neoplasia. N Engl J Med. 1984 Apr 5;310(14):880–883. doi: 10.1056/NEJM198404053101403. [DOI] [PubMed] [Google Scholar]
  4. Dürst M., Gissmann L., Ikenberg H., zur Hausen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3812–3815. doi: 10.1073/pnas.80.12.3812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gissmann L., Diehl V., Schultz-Coulon H. J., zur Hausen H. Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma. J Virol. 1982 Oct;44(1):393–400. doi: 10.1128/jvi.44.1.393-400.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heilman C. A., Law M. F., Israel M. A., Howley P. M. Cloning of human papilloma virus genomic DNAs and analysis of homologous polynucleotide sequences. J Virol. 1980 Nov;36(2):395–407. doi: 10.1128/jvi.36.2.395-407.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ikenberg H., Gissmann L., Gross G., Grussendorf-Conen E. I., zur Hausen H. Human papillomavirus type-16-related DNA in genital Bowen's disease and in Bowenoid papulosis. Int J Cancer. 1983 Nov 15;32(5):563–565. doi: 10.1002/ijc.2910320507. [DOI] [PubMed] [Google Scholar]
  8. Kremsdorf D., Favre M., Jablonska S., Obalek S., Rueda L. A., Lutzner M. A., Blanchet-Bardon C., Van Voorst Vader P. C., Orth G. Molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis. J Virol. 1984 Dec;52(3):1013–1018. doi: 10.1128/jvi.52.3.1013-1018.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kremsdorf D., Jablonska S., Favre M., Orth G. Biochemical characterization of two types of human papillomaviruses associated with epidermodysplasia verruciformis. J Virol. 1982 Aug;43(2):436–447. doi: 10.1128/jvi.43.2.436-447.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kremsdorf D., Jablonska S., Favre M., Orth G. Human papillomaviruses associated with epidermodysplasia verruciformis. II. Molecular cloning and biochemical characterization of human papillomavirus 3a, 8, 10, and 12 genomes. J Virol. 1983 Nov;48(2):340–351. doi: 10.1128/jvi.48.2.340-351.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lutzner M. A., Blanchet-Bardon C., Orth G. Clinical observations, virologic studies, and treatment trials in patients with epidermodysplasia verruciformis, a disease induced by specific human papillomaviruses. J Invest Dermatol. 1984 Jul;83(1 Suppl):18s–25s. doi: 10.1111/1523-1747.ep12281128. [DOI] [PubMed] [Google Scholar]
  12. Lutzner M. A., Orth G., Dutronquay V., Ducasse M. F., Kreis H., Crosnier J. Detection of human papillomavirus type 5 DNA in skin cancers of an immunosuppressed renal allograft recipient. Lancet. 1983 Aug 20;2(8347):422–424. doi: 10.1016/s0140-6736(83)90389-6. [DOI] [PubMed] [Google Scholar]
  13. Melton D. A., Krieg P. A., Rebagliati M. R., Maniatis T., Zinn K., Green M. R. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 1984 Sep 25;12(18):7035–7056. doi: 10.1093/nar/12.18.7035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Orth G., Jablonska S., Favre M., Croissant O., Obalek S., Jarzabek-Chorzelska M., Jibard N. Identification of papillomaviruses in butchers' warts. J Invest Dermatol. 1981 Feb;76(2):97–102. doi: 10.1111/1523-1747.ep12525394. [DOI] [PubMed] [Google Scholar]
  15. Ostrow R. S., Bender M., Niimura M., Seki T., Kawashima M., Pass F., Faras A. J. Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis. Proc Natl Acad Sci U S A. 1982 Mar;79(5):1634–1638. doi: 10.1073/pnas.79.5.1634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ostrow R. S., Zachow K. R., Thompson O., Faras A. J. Molecular cloning and characterization of a unique type of human papillomavirus from an immune deficient patient. J Invest Dermatol. 1984 Apr;82(4):362–366. doi: 10.1111/1523-1747.ep12260698. [DOI] [PubMed] [Google Scholar]
  17. Pfister H., Gassenmaier A., Nürnberger F., Stüttgen G. Human papilloma virus 5-DNA in a carcinoma of an epidermodysplasia verruciformis patient infected with various human papillomavirus types. Cancer Res. 1983 Mar;43(3):1436–1441. [PubMed] [Google Scholar]
  18. Pfister H., Haneke E. Demonstration of human papilloma virus type 2 DNA in Bowen's disease. Arch Dermatol Res. 1984;276(2):123–125. doi: 10.1007/BF00511069. [DOI] [PubMed] [Google Scholar]
  19. Pfister H., Hettich I., Runne U., Gissmann L., Chilf G. N. Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. J Virol. 1983 Aug;47(2):363–366. doi: 10.1128/jvi.47.2.363-366.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Scholl S. M., Pillers E. M., Robinson R. E., Farrell P. J. Prevalence of human papillomavirus type 16 DNA in cervical carcinoma samples in East Anglia. Int J Cancer. 1985 Feb 15;35(2):215–218. doi: 10.1002/ijc.2910350212. [DOI] [PubMed] [Google Scholar]
  21. Seedorf K., Krämmer G., Dürst M., Suhai S., Röwekamp W. G. Human papillomavirus type 16 DNA sequence. Virology. 1985 Aug;145(1):181–185. doi: 10.1016/0042-6822(85)90214-4. [DOI] [PubMed] [Google Scholar]
  22. Sutcliffe J. G. pBR322 restriction map derived from the DNA sequence: accurate DNA size markers up to 4361 nucleotide pairs long. Nucleic Acids Res. 1978 Aug;5(8):2721–2728. doi: 10.1093/nar/5.8.2721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Yutsudo M., Shimakage T., Hakura A. Human papillomavirus type 17 DNA in skin carcinoma tissue of a patient with epidermodysplasia verruciformis. Virology. 1985 Jul 15;144(1):295–298. doi: 10.1016/0042-6822(85)90328-9. [DOI] [PubMed] [Google Scholar]
  24. de Villiers E. M., Gissmann L., zur Hausen H. Molecular cloning of viral DNA from human genital warts. J Virol. 1981 Dec;40(3):932–935. doi: 10.1128/jvi.40.3.932-935.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES