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. 2008 Aug 21;105(34):12423–12428. doi: 10.1073/pnas.0806372105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 4. — Induction of type 2 effector responses in the absence of IL-4/STAT6 signaling. (A and B) Kinetics of blood (A) and BAL eosinophilia (B) after primary and secondary s.c. Nb infection were determined by flow cytometry in IL-4^+/+ (●), IL-4^G4/G4 (▲), IL-4^+/+STAT6^−/− (○), and IL-4^G4/G4STAT6^−/− (△) mice. (C) Serum IgE levels were determined by FBA in IL-4^+/+ (●), IL-4^+/G4 (■), and IL-4^G4/G4 (▲) mice infected with Nb as above. (D) Naïve IL-4^+/+, IL-4^+/G4, IL-4^G4/G4, IL-4^+/+ STAT6^−/−, IL-4^G4/G4 STAT6^−/−, and IL-4^G4/G4 STAT6^−/− mice were infected with Nb via s.c. injection. At day 15 after infection, peak serum IgE concentration was determined by FBA. Data points shown indicate mean ± SE from three individual animals. Data shown represent one independent experiment. *, IgE concentration below the limit of detection.