Fig. 3.

Blockade of IFNAR1 decreases the onset of T1D in WT NOD mice. (A) NOD mice were treated i.p. with 1 mg of anti-IFNAR1 (red) or control mAb (black) on days 15 and 20 after birth, and monitored for the onset of diabetes weekly (n = 10 per group). (B) Lymphocytes (1 × 10⁷) were prepared from anti-IFNAR1-treated (red) or control mAb-treated (black) 12-week-old NOD mice, transferred i.v. into 6- to 8-week-old female NOD/SCID mice (n = 10 per group). The onset of diabetes in the recipient mice was monitored twice a week. (C) Insulitis was scored in 10- to 12-week-old, anti-IFNAR1-treated (n = 7) or control mAb-treated (n = 6) mice.