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. Author manuscript; available in PMC: 2008 Sep 2.
Published in final edited form as: Neuroscience. 2005 Dec 1;138(3):1007–1014. doi: 10.1016/j.neuroscience.2005.06.015

Table 1.

Behavioral changes concomitant with variations in midbrain 3α,5α-THP

Dependent measures Experimental condition
Diestrus Behavior at estrus Biosynthesis inhibitor to VTA Metabolism inhibitor to VTA Biosynthesis and metabolism inhibitor to VTA OVX+SC E2+ vehicle to VTA OVX+SC E2+3α,5α-THP to VTA
Central entries# 6±1 17±6* 0±0# 2±1# 3±1# 13±12 98±8**
Open arm time (s) 28±4 110±12* 2±2# 9±6# 8±8# 21±12 34±5
Proximity to male (s) 84±13 119±11 16±2# 83±12# 20±4# 40±26 68±12**
Social interaction (s) 55±7 92±11* 19±3# 27±7# 28±4# 30±4 89±1**
Lordosis quotient (%) 10±2 94±2* 46±9# 50±3# 51±9# 25±6 75±11**
Midbrain 3α,5α-THP (nmol/g) 6±3 25±3* 13±1# 12±1# 11±1# 13±6 25±6**

All groups represent three to 12 observations per group.

*

Indicates that analyses of variance (ANOVAs) revealed these parameters were significantly different for rats in behavioral estrous and diestrous.

#

Represents that ANOVAs show that rats in behavioral estrus that were infused with the biosynthesis and/or metabolism inhibitors (digitoxin and finasteride, respectively) to the VTA are significantly different from rats in behavioral estrous infused with vehicle.

**

ANOVAs show that ovx, E2-primed rats with infusions of 3α,5α-THP to VTA are different from those that receive vehicle to the VTA.