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. 2008 May 9;4(5):e1000063. doi: 10.1371/journal.ppat.1000063

Figure 5. Inhibitors of serine protease HtrA2/Omi suppress cmvPCD.

Figure 5

(A) Percentage of dead GFP+ cells at 96 h postinfection with ΔUL37x1 (MOI of 0.01) in cultures treated with 100 µM TLCK from 30, 54, or 78 h postinfection relative to untreated cultures (U). 3000 cells/foci were evaluated at each condition. (B) Percentage dead GFP+ cells at 144 h postinfection with Towne-BAC (MOI of 0.03). 9000 cells/foci were evaluated at each condition. (C) Percentage of dead GFP+ cells at 96 h postinfection with ΔUL37x1 in cultures treated with 10 µM UCF-101 from 30, 54, or 78 h postinfection relative to untreated cultures (U). 3000 cells/foci were evaluated at each condition. (D) Percentage of dead GFP+ cells at 144 h postinfection with Towne-BAC (MOI of 0.03). A total of 9000 cells/foci were evaluated at each condition. Data in A–D is depicted relative to untreated controls, which were assigned a value of 100%. (E) Yields of virus at 168 h postinfection (MOI of 0.01) with ΔUL37x1 or Towne-BAC in untreated cultures or cultures treated with UCF-101 from 30 or 54 h postinfection.