Table I.
Matrix mutation
The procedure of matrix mutation improved the leave-one-out validation significantly, whereas the self-consistency performance was only moderately influenced. Here we fixed Sp at 90% to improve Sn by matrix mutation. PKC, protein kinase C; MAPKAPK, MAPK-activated protein kinase.
| PK cluster | Before MMa
|
After MMb
|
||
|---|---|---|---|---|
| Selfc | LOOd | Self | LOO | |
| % | % | |||
| AGC/PKA | 87.5 | 82.2 | 91.1 | 89.6 |
| AGC/PKC/α | 90.0 | 49.2 | 78.3 | 68.3 |
| Atypical/PIKK | 90.1 | 62.6 | 96.7 | 86.8 |
| CaMK/CaMKII/CaMKII-α | 100.0 | 69.0 | 100.0 | 93.1 |
| AGC/AKT | 96.4 | 86.9 | 98.8 | 92.9 |
| AGC/GRK | 90.5 | 52.3 | 98.8 | 61.9 |
| AGC/PKC | 72.7 | 64.1 | 79.2 | 75.0 |
| AGC/RSK | 98.2 | 76.8 | 100.0 | 83.9 |
| CaMK/CaMKII | 97.7 | 67.4 | 96.5 | 81.4 |
| CaMK/MAPKAPK | 100.0 | 43.8 | 100.0 | 62.5 |
| CMGC/CDK | 88.5 | 83.8 | 92.1 | 88.1 |
| Other/CK2 | 77.6 | 74.3 | 80.2 | 78.8 |
a
Before matrix mutation.
b
After matrix mutation.
c
Self, self-consistency Sn.
d
LOO, the Sn of leave-one-out validation.