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. Author manuscript; available in PMC: 2008 Sep 3.
Published in final edited form as: Endocrinology. 2006 Nov 30;148(3):1131–1143. doi: 10.1210/en.2006-1137

Fig. 2. The ERK/MAP kinase inhibitor PD98059 attenuates estradiol protection.

Fig. 2

Ovariectomized female rats were treated with estradiol or placebo for 14 days and subjected to global ischemia (white and black bars) or sham operation (grey bars). Animals received PD98059 (3 μg) or vehicle (10% DMSO) icv at 0 and 12 hr after ischemia. Global ischemia induced extensive death of pyramidal cells in the hippocampal CA1 at 7 days post-ischemia (P < 0.01 vs. sham). PD98059 greatly reduced estradiol protection, assessed at 7 days after surgery. Abbreviations as in Fig. 1. Scale bars: lower magnification, 400 μm; higher magnification, 60 μm. **, P < 0.01 vs. all sham groups; ‡, P < 0.01 ischemia+estradiol vs. ischemia or ischemia+estradiol+PD98059.