Table 1.
Patient demographics and baseline characteristics of the full cohort (n = 108) and for the activity questionnaire (AQ) subgroup (n = 46)
| Full cohort |
AQ subgroup |
|||
|---|---|---|---|---|
| Tiotropium | Placebo | Tiotropium | Placebo | |
| Total randomized (n) | 55 | 53 | 25 | 21 |
| Males (%) | 55 | 59 | 56 | 52 |
| Age (years)a | 65.9 (8.8) | 67.3 (6.9) | 67.6 (7.2) | 67.2 (7.4) |
| Duration of COPD (years)a | 9.7 (7.6) | 8.9 (6.6) | 9.8 (8.0) | 7.1 (4.4) |
| Smoking history (pack-years)a | 58.6 (34.6) | 58.8 (31.4) | 57.9 (32.5) | 50.2 (24.3) |
| Current smoker (%) | 29.1 | 18.9 | 20.0 | 23.8 |
| BMI (kg/cm2)a | 25.0 (4.6) | 26.8 (5.6) | 24.4 (5.4) | 26.2 (5.9) |
| FEV1 (L)a | 0.82 (0.31) | 0.94 (0.40) | 0.78 (0.28) | 0.91 (0.45) |
| FEV1 (% predicted)a | 32.6 (12.4) | 36.2 (12.2) | 31.5 (12.3) | 35.8 (12.4) |
| FVC (L)a | 2.01 (0.68) | 2.14 (0.85) | 1.91 (0.62) | 1.99 (0.87) |
| FEV1/FVC (%)a | 41.5 (10.4) | 44.6 (11.2) | 41.6 (10.6) | 46.0 (11.4) |
| Incremental treadmill test | ||||
| Maximum speed (mph)a | 2.98 (0.87) | 2.81 (0.98) | 3.13 (0.92) | 2.90 (0.98) |
| Endurance time (min)a | 8.96 (2.84) | 8.83 (3.60) | 9.16 (3.02) | 7.91 (2.34) |
| BDI focal scorea | 5.7 (2.1) | 5.7 (1.9) | 5.9 (2.2) | 5.9 (1.8) |
| SGRQ total scorea | 50.4 (15.4) | 46.6 (16.1) | 48.8 (16.2) | 47.6 (18.4) |
Abbreviations: BMI, body mass index; FEV1, forced respiratory volume in one second; FVC, forced vital capacity; BDI, baseline dyspnea index; SGRQ, St. George’s respiratory questionnaire.
Note: *Mean (SD).