TABLE 2.

Dosing suggestions of factor VIII (FVIII) and factor IX (FIX) for different clinical conditions

	Initial dose of FVIII (U/kg of body weight)*	Initial dose of FIX (U/kg of body weight)*
Minor bleeding	10–15	25–35
Early joint or muscle bleeding
Severe nose bleed
Persistent blood in urine
Mouth bleed that does not respond to antifibrinolytics
Major bleeding	20–30	45–70
Advanced joint or muscle bleed
Bleed into neck, tongue or throat
Prophylaxis following severe trauma without bleeding
Life-threatening bleeding	40–50	95–120
Severe head injury
Surgery (except dental)
Bleeding after major trauma
Bleeding into the abdomen
Dental extraction	10–15	25–35

*Vial sizes are typically 250 U, 500 U and 1000 U. Check with blood bank regarding availability of vial sizes