Figure 4.

PSN375963 and PSN632408 vary in their ability to augment glucose-stimulated insulin secretion in MIN6c4 cells. (a) MIN6c4 cells were stimulated with the indicated concentrations of PSN375963 in the presence of 2.8 mM glucose or 16 mM glucose (b) MIN6c4 cells were stimulated with the indicated concentrations of PSN632408 in the presence of 2.8 mM glucose or 16 mM glucose. For all experiments, the insulin levels were measured after 2 h incubation. Each treatment was performed in triplicate and data were presented as ng insulin per ml of culture supernatant (mean±s.e.mean). ^*P<0.05; using ANOVA-Bonferroni, compared with insulin induced by glucose alone.