Fig. 1.

Channel events are increased in GFP-tagged DAT-1. (A and B) Transporter channels from (A) WT and (B) BY320 C. elegans DA neurons in outside-out patches recorded at −120 mV. Single channel analysis revealed an open probability value of P = 0.002, and 0.0072 for channels recorded in WT and BY320 neurons, respectively. Data derive from n ≥ 8 neurons for each genotype. (C and D) Representative open-time histograms from DA-induced single-channel events shown in A and B, respectively. Channels with open time less than 4 ms were excluded to simplify the histograms.