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. Author manuscript; available in PMC: 2008 Sep 3.
Published in final edited form as: J Med Chem. 2007 May 10;50(11):2622–2639. doi: 10.1021/jm0613323

Figure 5.

Figure 5

3-Cl-AHPC analogues 31 and 43 inhibit the activity of SHP-2 and CD45 protein tyrosine phosphatases in cleaving 6,8-difluoro-4-methylumbelliferyl phosphate (100 µM) as measured by fluorescence spectrometry of the cleavage product as described in the Experimental Section. SHP-2 and CD45 concentrations were 5 nM and 1 nM, respectively. Tetrazole 31, solid diamond; thiazolidinedione 43, solid square. Results shown are the average of duplicates ± SE.