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. Author manuscript; available in PMC: 2009 Jun 6.
Published in final edited form as: J Mol Biol. 2008 Apr 10;379(3):443–456. doi: 10.1016/j.jmb.2008.04.010

Figure 3. Effects of the EMB-9a myosin isoform on myofibril assembly and stability in dorsal longitudinal IFM.

Figure 3

A, Transverse section from EMB late stage pupa. B, Transverse section from EMB-9a late stage pupa. Myofibril structure of EMB-9a shows cracking and disruption of the normal hexagonal packing of thick and thin filaments compared to EMB. The phenotype of EMB-9a pupa resembles that of EMB 2-day-old adult (E). C, Longitudinal section from EMB late stage pupa. D, Longitudinal section from EMB-9a late stage pupa. The sarcomere structure of EMB-9a is abnormal, Z-bands are slightly disrupted and M-lines are greatly disrupted compared to EMB sarcomeres. E, Transverse section from EMB two-day-old adult. Myofibrils show some abnormal hexagonal packing of thick and thin filaments. F, Transverse section from EMB-9a two-day-old adult. There is complete loss of myofibril shape, similar to the degeneration seen in EMB one-week-old adult (G). G, Transverse section from EMB one-week-old adult. H, Transverse section from EMB-9a one-week-old adult. In one-week-old adults, EMB and EMB-9a shown complete loss of myofibril shape and hexagonal packing of thick and thin filaments. Scale bars, 0.5 µm.