Table 3.

 Regression models for time without fever over first four hours (240 minutes) and no discomfort at 48 hours, adjusting for minimisation

Outcomes	Primary comparisons		Secondary comparison: ibuprofen v paracetamol
	Paracetamol plus ibuprofen v paracetamol	Paracetamol plus ibuprofen v ibuprofen
Time without fever in first 4 hours*:
Adjusted difference (minutes)	55.3	16.2	39.0
95% confidence interval	33.1 to 77.5†	−7.0 to 39.4†	15.9 to 61.0‡
P value	<0.001†	0.2†	<0.001‡
No discomfort at 48 hours§:
Adjusted odds ratio	1.33	0.89	1.50
95% confidence interval	0.49 to 3.56†	0.32 to 2.43†	0.53 to 4.26‡
P value	0.7†	>0.8†	>0.5‡

*Weighted by number of time points in first four hours contributing valid data on temperature. Positive differences indicate additional minutes below 37.2°C for first named treatment group compared with comparator.

†Primary comparisons after applying Dunnett’s correction (approximate P values obtained using extrapolation from limited published values²¹; uncorrected P values were <0.001 and 0.11 for time without fever, 0.53 and 0.79 for discomfort).

‡Secondary comparison after applying Tukey’s correction (P values obtained using interpolation from extensive published values²¹; <0.001 for temperature, 0.37 for discomfort).

§Odds of being well compared with not being well.