Table 4.

 Regression models for time without fever up to 24 hours, adjusting for minimisation

Outcomes	Primary comparisons		Secondary comparison: ibuprofen v paracetamol
	Paracetamol plus ibuprofen v paracetamol	Paracetamol plus ibuprofen v ibuprofen
Time until first fever clearance*:
Adjusted difference (minutes)	−23.5	3.0	−26.3
95% confidence interval	−44.8 to −2.2†	−18.3 to 24.4†	−48.3 to −4.3‡
P value	0.025†	>0.8†	0.015‡
Time without fever in first 24 hours§:
Adjusted difference (hours)	4.4	2.5	1.9
95% confidence interval	2.4 to 6.3†	0.6 to 4.4†	−0.2 to 4.0‡
P value	<0.001†	0.008†	0.076‡

*Negative differences indicate that first named treatment group has faster fever clearance time than comparator group.

†Primary comparisons after applying Dunnett’s correction (uncorrected P values were 0.016 and 0.75 for fever clearance, <0.001 and 0.005 for time without fever).

‡Secondary comparison after applying Tukey’s correction (uncorrected P values were 0.006 for fever clearance, 0.033 for time without fever).

§Weighted by number of time points in first 24 hours contributing valid data on temperature; positive differences indicate additional hours with temperature less than 37.2°C for first named treatment group than for comparator.